How does depression affect how the brain functions?
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Being depressed for very long period of time will change your brain. Neurons which fire together grow together. Basically thinking patterns reinforce each other. Being depressed means you have constant negative thinking patterns. Over time these become more and more engrained. You can call this damage. Depression will not actually destroy your brain however. This is reversable, but depending how severe your depression is, It may take a long time. The best way to go about it is a combination of excersise, meditation and therapy.
Depression and stress cause harm or damage to the brain for sure. The longer the stress and depression, the greater the harm. It is definitely reversible with proper lifestyle, diet, meditation and exercise, deep breathing. Pharmaceutical drugs only worsen the condition by masking the symptoms, which is what drugs mostly do. Seek a naturopathic doctor or herbal expert to guide you. The brain is resilient and can heal with the right treatment and conditions, but western medical treatment usually makes it worse in the long run.