There is no known effective cure for progeria, but several drugs are being studied for treating it. Physical therapy may help these children achieve good range of motion, balance and posture, and reduce pain in the hips and feet.

Occupational therapy can help them develop in functional areas such as eating, maintaining personal hygiene and handwriting. Children who have progeria can benefit greatly from care to help them live as healthy and comfortable a life as possible.
Monitoring for heart disease: This includes regular tests such as echocardiograms and checking blood pressure. Low-dose aspirin therapy and statin drugs can help reduce some risks of heart disease.

Regular eye exams: Some children with progeria have eye problems, including farsightedness or dry eyes (because their eyelids may not close completely). As the condition advances, they may also develop cataracts. These children may have thinner eyebrows and eyelashes, which can make it more likely that irritants can get in their eyes. Also, some children have a strong sensitivity to light and may be advised to wear sunglasses in some settings.

Hearing tests: Children who have progeria may have hearing loss that can be improved with hearing aids.

Regular dental exams: Children with progeria are more likely to have dental problems such as cavities, severe crowding, delayed arrival of teeth and recessed gums.

Monitoring for skin problems: These are often the first signs of progeria, and can include dark spots or bulges on the skin, hair loss, itching and skin tightness that restricts motion and can make it difficult to breathe or digest food.

Monitoring of bone health: Children with progeria may have several issues related to bone growth and development, as well as joint problems. Children with progeria need adequate nutrition to grow. Some may need supplemental nutrition.